Overactive bladder involves the symptoms of urgency, frequency, urge incontinence, and nocturia. Men and women with overactive bladder have lower quality of life, depression status, and poorer quality of sleep. Overactive bladder is also prevalent, affecting 16% of American adults, yet most of this group continues to suffer from bothersome symptoms.
AVAILABLE THERAPIES HAVE SIGNIFICANT WEAKNESSES
A fully-implantable, radically small device called eCoin® is implanted in the lower leg where it stimulates the tibial nerve.
HOW eCoin® FOR OAB WORKS
Stimulation of afferent tibial nerve fibers causes an inhibition of the micturition pathway in the spinal cord. From there, either the pelvic or the pudendal or both nerves act on the bladder to inhibit overactivity. Interestingly, the same spinal roots (L4-S3) are targeted by sacral nerve stimulation (SNS) but the response to SNS is acute and thus its mechanism is somewhat distinct.
eCoin® TIBIAL NERVE STIMULATION WORKS
Valencia conducted a feasibility study on 48 patients in the U.S. and New Zealand and that data has been published by the Journal of Urology. With 70% of patients improving in their urgency urinary incontinence by at least 50% and nearly a quarter of patients completely dry in their symptoms, eCoin demonstrated excellent effectiveness results. Furthermore, the eCoin® device– implanted in the lower leg in a 20 minute office or outpatient procedure– appears to have a benign safety profile in stark contrast to sacral neuromodulation.
eCoin® is an investigational device only and is not approved for sale in any country.Read More